Beacon, 340B ESP and Truzo: The Stack Covered Entities Need

Five platforms, five different jobs

In 2027, many covered entities will send overlapping claims data to several platforms, each serving a different program. Here is how they fit together. For the pilot itself, see our explainer on HRSA's revised rebate model.

Beacon, the rebate pilot platform

All 10 approved manufacturers use the Beacon Rebate Model Platform for pilot drugs. It is free for covered entities and handles submissions, claim status, denial documentation, payments and reconciliation reports.

Registration has two stages: verify your organization, then verify your bank account. Have these ready:

• EIN and IRS letter CP 575
• Articles of Incorporation (government entities can provide equivalent records)
• A current W-9
• A bank letter dated within the last 180 days, plus micro-deposit verification

Document review can take up to five business days, and Astellas suggests registering by December 26, 2026. If you registered for the 2025 pilot, you still need to upload a new bank letter and verify new micro-deposits.

340B ESP keeps running

The rebate pilot does not replace 340B ESP. Covered entities still submit there for non-pilot drugs under manufacturer claims data programs. For pilot drugs, AstraZeneca is the only manufacturer that still wants Farxiga claims in 340B ESP as well as Beacon. The other manufacturers moved their pilot drugs from ESP to Beacon.

Truzo, for manufacturer programs outside the pilot

Some manufacturers use Kalderos Truzo for their own claims data requirements and contract pharmacy policies. Like ESP, it keeps running alongside Beacon.

Two CMS systems that are separate from the 340B pilot

• Medicare Transaction Facilitator (MTF): handles Maximum Fair Price refunds to dispensing pharmacies. Disputes go through a Good Faith Inquiry process.
• CMS Part D 340B Repository: collects Part D 340B claims data so CMS can test whether it can identify 340B units for future inflation rebate calculations. It was set to open October 1, 2026, and participation is voluntary for 2026 dates of service.

Where Aventi fits

Aventi already submits to 340B ESP in real time, connects to Truzo, and is Beacon-ready for pharmacy and medical rebate claims. We also track Good Faith Inquiries and reconcile MFP alongside your 340B data, so each claim can be followed in one place.