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340B TPA comparison

340B TPA comparison: Aventi vs. Verity, PharmaForce, Macro Helix, Wellpartner, SunRx, NuvemRx, Sentry and Pillr

Choosing a 340B third-party administrator (TPA) for 2027? This page compares nine 340B TPAs on ownership, services, Beacon submissions, 340B rebate model readiness and fees, using only publicly available information.

Aventi Health is an independent 340B TPA: not owned by a wholesaler, PBM or pharmacy chain. Contingency-based pricing with no true-ups, and ready for 2027 340B rebate model submissions.

Last updated:

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Why Aventi

Why choose an independent 340B TPA?

Independent and founder-owned

Aventi has no outside owners: no wholesaler, PBM or pharmacy chain parent. We answer to our covered entity clients.

Contingency pricing, no true-ups

Aventi's TPA services for contract pharmacy and split billing are priced on contingency. Real-time claim capture and purchase splitting mean no end-of-month true-ups.

Ready for 2027 rebate submissions

Aventi is Beacon-ready for the HRSA 340B Rebate Model Pilot starting January 1, 2027, and already submits in-house pharmacy medical claims to Beacon.

See how 340B rebate submissions work

Rebate claim submission is a separate service: $750 per covered entity per month for covered entities that use another TPA, and included for Aventi TPA clients. Rebate model pricing

Side by side

340B TPA comparison table

Based on each company's public website, press releases and news coverage as of October 2, 2026. Where a company has not published something, we say so.

340B TPA comparison: ownership, services, Beacon submissions, rebate model readiness and fees. Fees reflect Aventi's relative estimate, not published pricing; $ = lowest.
340B TPAOwnershipContract pharmacySplit billingBeacon submissions2027 rebate model readiness (public statements)Fees
Aventi HealthIndependent, founder-owned[1]Yes[1]Yes[1]YesRebate claims plus in-house pharmacy medical claims[1][2]Beacon-ready for 2027 rebate claim submissions[1][2]$
Verity SolutionsOwned by Express Scripts (Cigna), acquired 2019; operates as a stand-alone company[3][4]Yes[5]Yes[5]YesAutomated rebate claim submission, pharmacy and medical[6][7]Described automated Beacon rebate claim submission for pharmacy and medical claims[6][7]$$
PharmaForceMajority investment by Aquiline Capital Partners (private equity), 2024[8]Yes[9]Yes[9]YesClaimsConnect direct Beacon connection[10]ClaimsConnect: direct Beacon connection for rebate submission and reconciliation[10]$$
Macro HelixMcKesson business unit[11]Yes[11]Yes[11]Not publicly statedSays it is preparing for the 2027 rebate pilot; submission details not publicly stated[12]$$$
WellpartnerAcquired by CVS Health in December 2017[13]Yes[14]Yes[14]Not publicly statedNot publicly stated$$$
SunRxParent company: MedImpact Healthcare Systems[15]Yes[15]Yes[15]YesCommand340B automated Beacon rebate submissions[16]Command340B: automated Beacon rebate submissions[16]$$$
NuvemRx (formerly Nuvem)Private equity-backed: Parthenon Capital growth recapitalization, 2020[17][18]Yes[19]Not publicly statedSays rebate pilot claims will be submitted automatically; platform not named[20]Rebate handling for the pilot is part of its standard service[20]$$$
Sentry Data Systems (Craneware)Acquired by Craneware plc in 2021; now part of The Craneware Group[21]YesSentrex[22]YesSentinel order splitting[22]YesPilot claims flow through Beacon, with workflows and reconciliation in Trisus[23]Says its customers can join the rebate pilot without a new vendor[23]$$$
Pillr HealthFormed in 2025 by merging RxStrategies, Hudson Headwaters 340B and RPH Innovations; Water Street Healthcare Partners (private equity) invested in January 2026[24][25]Yes[26]Yes[26]Registered as a supporting entity in Beacon; helps with setup, NDC mapping and claim routing[27]Says it is rebate model ready[27]$$

Fees reflect Aventi's relative estimate, not published pricing; $ = lowest.

Information is compiled from public sources listed below and may change. Product names are trademarks of their owners. Spot an error? Email hello@aventihealth.com and we will correct it.

Profiles

340B TPA alternatives: how each company describes itself

Aventi Health

Independent, founder-owned 340B TPA serving 300+ covered entities with a 10,000+ pharmacy network. Contract pharmacy and split billing on one platform, real-time 340B ESP and Truzo (Kalderos) integration, GFI tracking, and Beacon-ready rebate submissions.[1]

Verity Solutions

340B and pharmacy software company (V340B) acquired by Express Scripts in 2019 and run as a stand-alone company. Verity has said it can automate claim submissions to Beacon for eligible purchases at no additional cost to its clients.[3][4][7]

PharmaForce

340B TPA founded in 2017 that also offers an integrated PBM. Aquiline Capital Partners made a majority investment announced in January 2024. Its ClaimsConnect product submits rebate claims directly to Beacon.[8][9][10]

Macro Helix

340B software and services business of McKesson, offering 340B Architect for split billing and contract pharmacy administration, plus audit support.[11][12]

Wellpartner

340B administrator founded in 1999 and acquired by CVS Health in 2017. Solutions include 340B Confident (contract pharmacy), 340B Smart (split billing) and 340B Counter (in-house pharmacy). Wellpartner says it was the first administrator to offer performance-based pricing, in 2023.[13][14]

SunRx

340B administrator founded in 2006 whose parent company is MedImpact Healthcare Systems. Its Command340B suite includes automated Beacon rebate submissions.[15][16]

NuvemRx (formerly Nuvem)

Founded in 2013 as 340Basics, NuvemRx serves community health centers, FQHCs and Ryan White clinics with TPA (contract pharmacy), entity-owned pharmacy and specialty referral services. Parthenon Capital completed a growth recapitalization in 2020.[17][18][19]

Sentry Data Systems (Craneware)

Sentry's 340B products, including Sentrex for contract pharmacy and Sentinel for hospital procurement and order splitting, are now offered by The Craneware Group, which completed its acquisition of Sentry in July 2021.[21][22]

Pillr Health

Formed in February 2025 when RxStrategies, Hudson Headwaters 340B and RPH Innovations merged. Its Pillr One platform covers split billing, contract pharmacy and entity-owned pharmacies. Water Street Healthcare Partners invested in January 2026, buying it from Renovus Capital Partners.[24][25][26]

Buyer's checklist

How to choose the best 340B TPA

  • Ownership and independence: is the TPA owned by a wholesaler, PBM, pharmacy chain or investor, and could that create conflicting incentives?
  • Services: contract pharmacy, split billing for mixed-use areas, and owned or in-house pharmacy support.
  • 2027 rebate model readiness: can the TPA submit rebate claims to Beacon, track denials and reconcile payments?
  • Pricing: is pricing contingency-based, flat or per-claim, and are there true-ups?
  • Integrations: 340B ESP, Truzo (Kalderos) and Beacon.

Preparing for rebates? Read our 340B rebate model guide.

FAQ

340B TPA FAQ

A 340B third-party administrator (TPA) helps a covered entity run its 340B program: identifying eligible claims at contract pharmacies, splitting purchases in mixed-use areas (split billing), keeping records audit-ready, and submitting claims data to manufacturers and platforms such as 340B ESP and Beacon.

The best 340B TPA depends on your program. Compare ownership and independence, services (contract pharmacy, split billing, in-house pharmacy), readiness for the 2027 340B rebate model, and how pricing works. Aventi Health is an independent, founder-owned option with contingency-based pricing, no true-ups, and Beacon-ready rebate submissions.

Among the TPAs compared on this page, Aventi Health is independent and founder-owned. Verity Solutions is owned by Express Scripts (Cigna), Macro Helix is part of McKesson, Wellpartner was acquired by CVS Health, SunRx's parent company is MedImpact Healthcare Systems, Sentry Data Systems is part of The Craneware Group, and PharmaForce, NuvemRx and Pillr Health are backed by private equity firms (Aquiline Capital Partners, Parthenon Capital and Water Street Healthcare Partners), based on public sources as of October 2, 2026.

Aventi's TPA services for contract pharmacy and split billing are contingency-based, with no true-ups. Rebate claim submission is a separate service at $750 per covered entity per month for covered entities that use another TPA, and is included for Aventi TPA clients.

Yes. Aventi is Beacon-ready for the HRSA 340B Rebate Model Pilot starting January 1, 2027, and already submits in-house pharmacy medical claims to Beacon. See aventihealth.com/340b-rebate-model for details.

Yes. Aventi's rebate claim submission service works even if Aventi is not your TPA, for $750 per covered entity per month.

Commonly compared 340B TPAs include Aventi Health, Verity Solutions, PharmaForce, Macro Helix, Wellpartner, SunRx, NuvemRx, Sentry Data Systems (Craneware) and Pillr Health. Aventi is the independent, founder-owned alternative on this list.

Based on public statements as of October 2, 2026, Aventi Health, Verity Solutions, PharmaForce, SunRx and The Craneware Group (Sentry) describe submitting or routing 340B rebate claims through Beacon. Pillr Health says it is registered as a supporting entity in Beacon, and NuvemRx says rebate pilot claims will be submitted automatically. Macro Helix and Wellpartner have not publicly described Beacon submissions.

Sources

  1. Aventi Health home page — https://aventihealth.com/
  2. Aventi Health, 340B Rebate Model — https://aventihealth.com/340b-rebate-model
  3. Nasdaq / Business Wire, "Ignition Partners Congratulates Verity Solutions on Its Acquisition by Express Scripts" (Oct 17, 2019) — https://www.nasdaq.com/press-release/ignition-partners-congratulates-verity-solutions-on-its-acquisition-by-express
  4. GeekWire, "Cigna-owned Express Scripts buys Seattle-area health tech startup Verity Solutions" (2019) — https://www.geekwire.com/2019/cigna-owned-express-scripts-buys-seattle-area-health-tech-startup-verity-solutions/
  5. Verity Solutions website — https://www.verity-solutions.com/, https://verity-solutions.com/solution/owned-outpatient-pharmacy/
  6. Verity Solutions, "The 340B Rebate Model Pilot Was Approved. Are You Ready for What's Next?" — https://verity-solutions.com/the-340b-rebate-model-pilot-is-approved/
  7. Verity Solutions, "Your 340B Rebate Model Pilot and MFP Checklist" — https://verity-solutions.com/your-340b-rebate-model-pilot-and-mfp-checklist/
  8. PR Newswire, "PharmaForce Announces Significant Investment from Aquiline Capital Partners" (Jan 16, 2024) — https://www.prnewswire.com/news-releases/pharmaforce-announces-significant-investment-from-aquiline-capital-partners-302035736.html
  9. PharmaForce home and About Us — https://thepharmaforce.com/, https://thepharmaforce.com/about-us
  10. PharmaForce, 340B Rebate Management (ClaimsConnect) — https://thepharmaforce.com/automate-340b-rebate-compliance-and-reporting-claimsconnect
  11. McKesson, "Macro Helix: 340B Program Software & Services" — https://www.mckesson.com/pharmacy-technology/business-units/macro-helix/
  12. Macro Helix on LinkedIn, "HRSA Announces Revised 340B Rebate Pilot" (Aug 2026) — https://www.linkedin.com/posts/macro-helix-inc_340b-340bprogram-hrsa-activity-7490472159006425088-KB9i
  13. Wellpartner, About Us (company timeline) — https://www.wellpartner.com/about-us.html
  14. Wellpartner 340B solutions — https://www.wellpartner.com/340b-solutions/340b-confident.html, https://www.wellpartner.com/340b-solutions/340b-smart.html, https://www.wellpartner.com/340b-solutions/340b-counter.html
  15. SunRx, Who We Are — https://www.sunrx.com/who-we-are
  16. SunRx, Command340B overview (PDF, 2026) — https://www.sunrx.com/sites/default/files/2026-02/Command340B-Overview-and-FAQ_Assist-Edge-ACC-Overviews.pdf
  17. NuvemRx, "NuvemRx Invests In Expanded Leadership" — https://www.nuvemrx.com/news/press-release-nuvem-invests-in-expanded-leadership
  18. Parthenon Capital, "Parthenon Capital Completes Growth Recapitalization of Nuvem" (July 22, 2020) — https://www.parthenoncapital.com/news/parthenon-capital-completes-growth-recapitalization-of-nuvem/, https://www.parthenoncapital.com/investment/nuvem/
  19. NuvemRx home page — https://www.nuvemrx.com/
  20. NuvemRx, "Getting ready for the 340B rebate pilot: six things to do before January" (Aug 28, 2026) — https://www.nuvemrx.com/blog/getting-ready-for-the-340b-rebate-pilot-six-things-to-do-before-january
  21. PR Newswire, "Craneware Completes Acquisition of Sentry Data Systems" (July 13, 2021) — https://www.prnewswire.com/news-releases/craneware-completes-acquisition-of-sentry-data-systems-301332107.html
  22. The Craneware Group, Sentrex and Sentinel — https://www.thecranewaregroup.com/solutions/340b-pharmacy/sentrex340b-contract-pharmacy-management/, https://www.thecranewaregroup.com/media/aabb1dji/fs_sentinel-info-sheet-mktg.pdf
  23. The Craneware Group, "The Craneware Group Hosts 340B Rebate Forum, Confirms No New Vendor Needed for Pilot" (2025) — https://www.thecranewaregroup.com/news-events/press-releases/2025/the-craneware-group-hosts-340b-rebate-forum-confirms-no-new-vendor-needed-for-pilot/
  24. PR Newswire, "RxStrategies, Hudson Headwaters 340B, and RPH Innovations Merge to Form Pillr Health" (Feb 4, 2025) — https://www.prnewswire.com/news-releases/rxstrategies-hudson-headwaters-340b-and-rph-innovations-merge-to-form-pillr-health-302367560.html
  25. Water Street, "Water Street Invests in Pillr Health" (Jan 2026) and Business Wire, "Renovus Capital Partners Announces Sale of Pillr Health" — https://waterstreet.com/news/water-street-invests-in-pillr-health, https://www.businesswire.com/news/home/20260119858580/en/Renovus-Capital-Partners-Announces-Sale-of-Pillr-Health
  26. Pillr Health, Pillr One and Contract Pharmacy — https://www.pillrhealth.com/solutions/pillr-one, https://www.pillrhealth.com/solutions/contract-pharmacy
  27. Pillr Health, 340B Rebate Readiness — https://www.pillrhealth.com/solutions/340b-rebate-readiness

Accessed October 2, 2026.

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